rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8
|
pubmed:dateCreated |
2005-12-5
|
pubmed:abstractText |
Besides its important role in immune response and inflammatory processes the cytokine interleukin-6 (IL-6) is crucially involved in carcinogenesis. A common polymorphism within the gene encoding IL-6 (IL6) is known to alter IL-6 protein expression and has been associated with patients' prognosis in various malignancies. No data are available with respect to vulvar cancer. Therefore, we determined the prognostic potential of the common -174(G-->C) single nucleotide polymorphism in the promoter region of IL6 in a series of patients with this disease.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1556-7117
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
617-20
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16198606-Aged,
pubmed-meshheading:16198606-Female,
pubmed-meshheading:16198606-Genotype,
pubmed-meshheading:16198606-Humans,
pubmed-meshheading:16198606-Interleukin-6,
pubmed-meshheading:16198606-Logistic Models,
pubmed-meshheading:16198606-Middle Aged,
pubmed-meshheading:16198606-Multivariate Analysis,
pubmed-meshheading:16198606-Neoplasm Staging,
pubmed-meshheading:16198606-Neoplasms, Squamous Cell,
pubmed-meshheading:16198606-Polymorphism, Genetic,
pubmed-meshheading:16198606-Prognosis,
pubmed-meshheading:16198606-Proportional Hazards Models,
pubmed-meshheading:16198606-Prospective Studies,
pubmed-meshheading:16198606-Survival Analysis,
pubmed-meshheading:16198606-Vulvar Neoplasms
|
pubmed:year |
2005
|
pubmed:articleTitle |
A common interleukin-6 promoter polymorphism in patients with vulvar cancer.
|
pubmed:affiliation |
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|