Linked Life Data

16198008

Source:http://linkedlifedata.com/resource/pubmed/id/16198008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-17
pubmed:abstractText
Sensitization of dopaminergic neural reward circuits has been hypothesized to be involved in the development of drug addiction. Highly palatable foods activate these same brain areas, specifically the nucleus accumbens. In this study, the effects of a highly palatable food (sucrose) on these circuits were investigated using the dopamine D(2)/D(3) receptor agonist quinpirole. Male Long-Evans rats received 30 min daily access to 0.3 M sucrose solution or water over nine consecutive days, followed by nine daily injections of quinpirole (0.5 mg/kg, s.c.) or saline. Locomotor activity was assessed using an automated open-field system. Locomotor sensitization developed, as quinpirole-treated rats traveled significantly more, and exhibited a greater number of movements than saline controls. A characteristic pattern of an initial suppression of locomotor activity, followed by excitation of activity was observed in quinpirole-treated rats. Pre-exposure to sucrose attenuated the initial suppression of activity, and facilitated excitation of activity. Rats that were pre-exposed to sucrose exhibited a reduced suppression of activity as compared to rats pre-exposed to water. Rats receiving sucrose and quinpirole also displayed a significantly greater enhancement of locomotor activity as compared to rats receiving water and quinpirole. These results support the hypothesis that highly palatable foods can alter the same neural reward circuits as drugs of abuse, and may facilitate sensitization-related addiction. This may aid in further understanding the neural basis of eating disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Quinpirole-induced behavioral sensitization is enhanced by prior scheduled exposure to sucrose: A multi-variable examination of locomotor activity.
pubmed:affiliation
Neuroscience Graduate Program, Psychology Department, Social Science Centre Room 7418, University of Western Ontario, London, Ont., Canada N6A 5C2. kfoley@uwo.ca
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't