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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-9-29
pubmed:abstractText
Understanding of vascular substrates of cognitive decline in the elderly is evolving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correlations from patient to patient. The range and significance of lesions that should be included as manifestations of SVD are unresolved, as is their impact on, and association with, neurodegenerative changes. This mini-review summarizes the authors' views on SVD substrates leading to cognitive decline and proposes priorities for pathological investigations of human cerebrovascular mechanisms leading to cognitive decline.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1041-6102
pubmed:author
pubmed:issnType
Print
pubmed:volume
15 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-5
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Neuropathology of vascular cognitive impairment and vascular dementia.
pubmed:affiliation
Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK. p.g.ince@shef.ac.uk
pubmed:publicationType
Journal Article