Source:http://linkedlifedata.com/resource/pubmed/id/16184177
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2006-1-4
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| pubmed:abstractText |
We retrospectively analysed the significance of FLT3 mutations in patients with acute myeloid leukemia (AML) having a normal karyotype, who were treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation (auto-PBSCT). In all, 34 patients with normal karyotype AML in first complete remission receiving high-dose chemotherapy and auto-PBSCT were analysed based on the presence or absence of FLT3/ITDs and FLT3/D835. They were 16 males and 18 females and with a median age of 41.5 years. FLT3/ITDs were detected in eight of 34 patients (23.5 %), and FLT3 D835 mutations in two of 34 patients (5.9%). White blood cell count (P=0.0087), serum concentration of lactate dehydrogenase (P=0.005), and percentages of peripheral blood (P=0.0131) and bone marrow (BM) blasts (P=0.0312) were significantly higher in patients showing the FLT3 mutations. Overall survival (OS) and disease-free survival (DFS) were similar between patients with or without FLT3 mutations (5 year DFS, 67.5 vs 68.55%, P=0.819; 5 year OS, 64.81 vs 78.88%, P=0.4457, by the log-rank test). FLT3 mutations demonstrate no further prognostic impact in patients with normal karyotype AML in first CR treated with high-dose chemotherapy and auto-PBSCT. Myeloablative chemotherapy supported by auto-PBSCT may overcome any poor prognostic implications of FLT3 mutations.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
36
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
977-83
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16184177-Acute Disease,
pubmed-meshheading:16184177-Adolescent,
pubmed-meshheading:16184177-Adult,
pubmed-meshheading:16184177-Aged,
pubmed-meshheading:16184177-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16184177-DNA Mutational Analysis,
pubmed-meshheading:16184177-Female,
pubmed-meshheading:16184177-Humans,
pubmed-meshheading:16184177-Karyotyping,
pubmed-meshheading:16184177-Leukemia, Myeloid,
pubmed-meshheading:16184177-Male,
pubmed-meshheading:16184177-Middle Aged,
pubmed-meshheading:16184177-Mutation,
pubmed-meshheading:16184177-Mutation, Missense,
pubmed-meshheading:16184177-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:16184177-Prognosis,
pubmed-meshheading:16184177-Remission Induction,
pubmed-meshheading:16184177-Retrospective Studies,
pubmed-meshheading:16184177-Survival Analysis,
pubmed-meshheading:16184177-Tandem Repeat Sequences,
pubmed-meshheading:16184177-Transplantation, Autologous,
pubmed-meshheading:16184177-fms-Like Tyrosine Kinase 3
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| pubmed:year |
2005
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| pubmed:articleTitle |
FLT3 mutations in normal karyotype acute myeloid leukemia in first complete remission treated with autologous peripheral blood stem cell transplantation.
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| pubmed:affiliation |
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
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| pubmed:publicationType |
Journal Article
|