|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
24
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pubmed:dateCreated |
2005-11-1
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pubmed:abstractText |
Several novel 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-(N-aryl) carboxamides were prepared by reaction of pyridoxal hydrochloride with various N-arylcyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25microg/mL), displaying comparable or even better efficacy than the standard drugs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
5483-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides.
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|
pubmed:affiliation |
National Pharmaceutical University, Kharkiv, Ukraine.
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|
pubmed:publicationType |
Journal Article,
Comparative Study
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