Linked Life Data

16182496

Source:http://linkedlifedata.com/resource/pubmed/id/16182496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-10-24
pubmed:abstractText
This paper reviews the early features of Rett syndrome (RTT). The behavioral characteristics of RTT were analyzed retrospectively by taking history and asking about early infancy behaviors. The earliest behavioral characteristics are thought to be autistic features and hypotonia of trunkal muscles. Analysis of sleep-wake rhythm and all-night polysomnography suggested that the initial lesion is serotonergic and noradrenargic hypofunction at brainstem level. Dopaminergic (DA) hypofunction associated with DA receptor supersensitivity follows as the brain matures. Characteristic symptoms developing at specific age ranges are based on the neuronal connections of the brainstem aminergic neurons and DA neurons with the pedunculo-pontine nuclei, projecting to specific cortical areas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0387-7604
pubmed:author
pubmed:issnType
Print
pubmed:volume
27 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S35-S42
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Early behavior characteristics and sleep disturbance in Rett syndrome.
pubmed:affiliation
Segawa Neurological Clinic for Children, 2-8 Surugadai Kanda Chiyodaku, Tokyo 101-0062, Japan. nomura-y@segawa-clinic.jp
pubmed:publicationType
Journal Article, Review