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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7058
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pubmed:dateCreated |
2005-9-22
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pubmed:databankReference |
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pubmed:abstractText |
Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1476-4687
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pubmed:author |
pubmed-author:AbouelleilAmrA,
pubmed-author:AllenNicole RNR,
pubmed-author:AndersonScottS,
pubmed-author:BirrenBruce WBW,
pubmed-author:BloomTobyT,
pubmed-author:BorowskyMark LML,
pubmed-author:BugalterBorisB,
pubmed-author:ButlerJonathanJ,
pubmed-author:ChangJean LJL,
pubmed-author:CookAprilA,
pubmed-author:CuomoChristina ACA,
pubmed-author:DeCaprioDavidD,
pubmed-author:DewarKenK,
pubmed-author:EngelsReinhardR,
pubmed-author:FitzGeraldMichael GMG,
pubmed-author:FujiyamaAsaoA,
pubmed-author:GarberManuelM,
pubmed-author:GnirkeAndreasA,
pubmed-author:HallJennifer LJL,
pubmed-author:HattoriMasahiraM,
pubmed-author:ItohTakehikoT,
pubmed-author:JaffeDavid BDB,
pubmed-author:KamalMichaelM,
pubmed-author:KodiraChinnappa DCD,
pubmed-author:KurokiYokoY,
pubmed-author:LanderEric SES,
pubmed-author:LehoczkyJessicaJ,
pubmed-author:LuiAnnieA,
pubmed-author:MacdonaldPendexterP,
pubmed-author:MauceliEvanE,
pubmed-author:MikkelsenTarjei STS,
pubmed-author:NaylorJerome WJW,
pubmed-author:NguyenCindyC,
pubmed-author:NicolRobertR,
pubmed-author:NoguchiHidekiH,
pubmed-author:NormanCatherine HosageCH,
pubmed-author:NusbaumChadC,
pubmed-author:O'LearySinéad BSB,
pubmed-author:O'NeillKeithK,
pubmed-author:PiqaniBrunoB,
pubmed-author:SakakiYoshiyukiY,
pubmed-author:SmithCherylyn LCL,
pubmed-author:TalamasJessica AJA,
pubmed-author:TaylorTodd DTD,
pubmed-author:TophamKerriK,
pubmed-author:TotokiYasushiY,
pubmed-author:ToyodaAtsushiA,
pubmed-author:VA Cooperative Study #470 Study Group,
pubmed-author:WainHester MHM,
pubmed-author:WhittakerCharles ACA,
pubmed-author:YangXiaopingX,
pubmed-author:YoungSarah KSK,
pubmed-author:ZengQiandongQ,
pubmed-author:ZimmerAndrew RAR,
pubmed-author:ZodyMichael CMC
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
437
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
551-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16177791-Aneuploidy,
pubmed-meshheading:16177791-Animals,
pubmed-meshheading:16177791-Chromosomes, Human, Pair 18,
pubmed-meshheading:16177791-Conserved Sequence,
pubmed-meshheading:16177791-CpG Islands,
pubmed-meshheading:16177791-DNA,
pubmed-meshheading:16177791-Exons,
pubmed-meshheading:16177791-Expressed Sequence Tags,
pubmed-meshheading:16177791-Genes,
pubmed-meshheading:16177791-Genome, Human,
pubmed-meshheading:16177791-Humans,
pubmed-meshheading:16177791-Introns,
pubmed-meshheading:16177791-Molecular Sequence Data,
pubmed-meshheading:16177791-Sequence Analysis, DNA,
pubmed-meshheading:16177791-Synteny
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pubmed:year |
2005
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pubmed:articleTitle |
DNA sequence and analysis of human chromosome 18.
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pubmed:affiliation |
Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02141, USA. chad@broad.mit.edu
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pubmed:publicationType |
Journal Article,
Comparative Study
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