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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0008497,
umls-concept:C0012854,
umls-concept:C0019648,
umls-concept:C0086418,
umls-concept:C0181427,
umls-concept:C0525026,
umls-concept:C0547047,
umls-concept:C0871261,
umls-concept:C1335807,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
10
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pubmed:dateCreated |
2005-9-22
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pubmed:abstractText |
We tested the hypothesis that biotinylation of K12 in histone H4 plays a role in the cellular response to double-strand breaks (DSB) of DNA in human cells. DSB were caused by treating choriocarcinoma JAr cells with etoposide. Biotinylation of K12 in histone H4 decreased by 50% as early as 10-20 min after initiation of treatment with etoposide. Biotinylation returned to initial levels 30-40 min after the addition of etoposide to the medium. Temporal patterns of K12-biotinylation were similar for human lymphoma cells. Phosphorylation of S14 of histone H2B and poly(ADP-ribosylation) of glutamate residues on histone H2A are known markers of DSB in DNA; these modifications increased 10-40 min after alterations in K12-biotinylation occurred. Decreased biotinylation of K12 of histone H4 was specific for DSB but was not detectable in response to single-strand breaks or the formation of thymine dimers. Biotin-deficient choriocarcinoma cells exhibited a 40% decrease in rates of survival in response to etoposide compared with biotin-sufficient controls. These studies suggest that the lack of biotinylation of K12 in histone H4 is an early signaling event in response to DSB.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-10343652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-10455009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-10632957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-10638745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11048728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11286477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11395493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11517308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11606205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-11983808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12070309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12082144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12136930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12142523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12176744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12498683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12556884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12612142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12757711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-12954769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-14613969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-14743551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-14991266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-15153116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-15197225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-15338042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-15603433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-15665826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-1779651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-2387872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-2726732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-3359995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-3409869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-3964683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-410154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-6848489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-8422685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-8593541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-9164991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-9349849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16177192-9518481
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3166
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2337-42
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16177192-Humans,
pubmed-meshheading:16177192-Serine,
pubmed-meshheading:16177192-Lysine,
pubmed-meshheading:16177192-Phosphorylation,
pubmed-meshheading:16177192-Histones,
pubmed-meshheading:16177192-Choriocarcinoma,
pubmed-meshheading:16177192-DNA,
pubmed-meshheading:16177192-Biotin,
pubmed-meshheading:16177192-Cell Survival,
pubmed-meshheading:16177192-Antineoplastic Agents, Phytogenic
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