Source:http://linkedlifedata.com/resource/pubmed/id/16170579
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-9-19
|
| pubmed:abstractText |
Matrix-induced autologous chondrocyte implantation (MACI) is a tissue-engineering technique for the treatment of full-thickness articular cartilage defects and requires the use of a three-dimensional collagen type I-III membrane seeded with cultured autologous chondrocytes. The cell-scaffold construct is implanted in the debrided cartilage defect and fixed only with fibrin glue, with no periosteal cover or further surgical fixation. In a clinical pilot study, the MACI technique was used for the treatment of full-thickness, weight-bearing chondral defects of the femoral condyle in 16 patients. All patients were followed prospectively and the early postoperative attachment rate, 34.7 days (range: 22-47) after the scaffold implantation, was determined. With the use of high-resolution magnetic resonance imaging (MRI), the transplant was graded as completely attached, partially attached, or detached. In 14 of 16 patients (87.5%), a completely-attached graft was found, and the cartilage defect site was totally covered by the implanted scaffold and repair tissue. In one patient (6.25%), a partial attachment occurred with partial filling of the chondral defect. A complete detachment of the graft was found in one patient (6.25%), which resulted in an empty defect site with exposure of the subchondral bone. Interobserver variability for the MRI grading of the transplants showed substantial agreement (kappa=0.775) and perfect agreement (kappa(w)=0.99). In conclusion, the implantation and fixation of a cell-scaffold construct in a deep cartilage defect of the femoral condyle with fibrin glue and with no further surgical fixation leads to a high attachment rate 34.7 days after the implantation, as determined with high resolution MRI.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0942-2056
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
451-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16170579-Adult,
pubmed-meshheading:16170579-Arthroscopy,
pubmed-meshheading:16170579-Cartilage, Articular,
pubmed-meshheading:16170579-Cells, Cultured,
pubmed-meshheading:16170579-Chondrocytes,
pubmed-meshheading:16170579-Female,
pubmed-meshheading:16170579-Femur,
pubmed-meshheading:16170579-Fibrin Tissue Adhesive,
pubmed-meshheading:16170579-Graft Survival,
pubmed-meshheading:16170579-Humans,
pubmed-meshheading:16170579-Knee Joint,
pubmed-meshheading:16170579-Magnetic Resonance Imaging,
pubmed-meshheading:16170579-Male,
pubmed-meshheading:16170579-Motion Therapy, Continuous Passive,
pubmed-meshheading:16170579-Pilot Projects,
pubmed-meshheading:16170579-Prospective Studies,
pubmed-meshheading:16170579-Tissue Adhesives,
pubmed-meshheading:16170579-Tissue Engineering,
pubmed-meshheading:16170579-Transplantation, Autologous,
pubmed-meshheading:16170579-Weight-Bearing
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle.
|
| pubmed:affiliation |
Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. stefan.marlovits@akh-wien.ac.at
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|