Linked Life Data

16156511

Source:http://linkedlifedata.com/resource/pubmed/id/16156511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-9-13
pubmed:abstractText
The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. The density of immunocytochemically stained nerve fibers in the mesenteric artery was quantified by computer-assisted image processing. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fivers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar Kyoto rats (WKY). The density of NPY-LI-containing sympathetic nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan) or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured by tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. However, the density after hydralazine treatment was similar to the level in non-treated SHR. The density of NPY-LI-containing nerve fibers was not increased by any of the drug treatments. These results suggest that long-term inhibition of the renin-angiotensin system in SHR prevents remodeling of CGRPergic nerve fibers and prevents the reduction of CGRPergic nerve function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0916-9636
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16156511-Aging, pubmed-meshheading:16156511-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:16156511-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:16156511-Animals, pubmed-meshheading:16156511-Calcitonin Gene-Related Peptide, pubmed-meshheading:16156511-Cell Count, pubmed-meshheading:16156511-Hydralazine, pubmed-meshheading:16156511-Hypertension, pubmed-meshheading:16156511-Immunohistochemistry, pubmed-meshheading:16156511-Losartan, pubmed-meshheading:16156511-Male, pubmed-meshheading:16156511-Mesenteric Arteries, pubmed-meshheading:16156511-Nerve Fibers, pubmed-meshheading:16156511-Neuropeptide Y, pubmed-meshheading:16156511-Rats, pubmed-meshheading:16156511-Rats, Inbred SHR, pubmed-meshheading:16156511-Rats, Inbred WKY, pubmed-meshheading:16156511-Renin-Angiotensin System, pubmed-meshheading:16156511-Sympathetic Nervous System, pubmed-meshheading:16156511-Thiazepines, pubmed-meshheading:16156511-Vasodilator Agents
pubmed:year
2005
pubmed:articleTitle
Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats.
pubmed:affiliation
Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't