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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-13
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pubmed:abstractText |
Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 microg EX blocked the feeding inhibitory action of 1 microg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Sincalide,
http://linkedlifedata.com/resource/pubmed/chemical/Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/cocaine- and amphetamine-regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/cocaine- and amphetamine-regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/exenatide,
http://linkedlifedata.com/resource/pubmed/chemical/glucagon-like peptide 1 (7-36)amide,
http://linkedlifedata.com/resource/pubmed/chemical/glucagon-like peptide receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-64
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pubmed:meshHeading |
pubmed-meshheading:16154233-Animals,
pubmed-meshheading:16154233-Brain,
pubmed-meshheading:16154233-Feeding Behavior,
pubmed-meshheading:16154233-Gene Expression Regulation,
pubmed-meshheading:16154233-Glucagon-Like Peptide 1,
pubmed-meshheading:16154233-Immunohistochemistry,
pubmed-meshheading:16154233-Injections, Intraventricular,
pubmed-meshheading:16154233-Male,
pubmed-meshheading:16154233-Nerve Tissue Proteins,
pubmed-meshheading:16154233-Neurotransmitter Agents,
pubmed-meshheading:16154233-Peptide Fragments,
pubmed-meshheading:16154233-Peptides,
pubmed-meshheading:16154233-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:16154233-Rats,
pubmed-meshheading:16154233-Rats, Sprague-Dawley,
pubmed-meshheading:16154233-Receptors, Glucagon,
pubmed-meshheading:16154233-Sincalide,
pubmed-meshheading:16154233-Venoms
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pubmed:year |
2006
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pubmed:articleTitle |
Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression.
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pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA. saja1@jhmi.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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