|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0063486,
umls-concept:C0166417,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0243192,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C0728938,
umls-concept:C1883254
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|
pubmed:issue |
22
|
|
pubmed:dateCreated |
2005-10-5
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|
pubmed:abstractText |
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARgamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5035-8
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|
pubmed:meshHeading |
pubmed-meshheading:16153845-Animals,
pubmed-meshheading:16153845-Blood Glucose,
pubmed-meshheading:16153845-Disease Models, Animal,
pubmed-meshheading:16153845-Humans,
pubmed-meshheading:16153845-Indoles,
pubmed-meshheading:16153845-Inhibitory Concentration 50,
pubmed-meshheading:16153845-Male,
pubmed-meshheading:16153845-Mice,
pubmed-meshheading:16153845-Molecular Structure,
pubmed-meshheading:16153845-PPAR gamma,
pubmed-meshheading:16153845-Structure-Activity Relationship,
pubmed-meshheading:16153845-Titrimetry
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.
|
|
pubmed:affiliation |
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. James_Dropinski@merck.com
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pubmed:publicationType |
Journal Article
|
