Source:http://linkedlifedata.com/resource/pubmed/id/16148456
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
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| pubmed:dateCreated |
2005-9-8
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| pubmed:abstractText |
Newly developed cannabinoids may hold the promise of the development of useful and safe drugs. This study aimed to investigate the behavioral effects of the novel 1',1'-dithiolane delta8-HC analogue AMG-3, a cannabinomimetic molecule with high affinity for CB1/CB2 receptors. This analog was chosen for its binding affinity to these receptors, which is higher than that reported for delta8-tetrahydrocannabinol (delta8-THC). Behavioral responses were assessed after the administration of AMG-3 (1, 2, 4, 8 mg/kg, i.p.) in the open field, on the bar test, on the hot plate and in the intracranial self-stimulation procedure. AMG-3 increased the reactivity time on the hot plate in a dose- and time-dependent manner, indicating a long-lasting analgesic effect (at least 24 h). The substance was found dose-dependently to decrease spontaneous motor activity and to induce catalepsy, particularly at the highest dose (8 mg/kg). AMG-3 did not affect the rewarding value of intracranial self-stimulation, except to increase the reward threshold at the highest dose (8 mg/kg). The effects of the highest dose of AMG-3 on spontaneous activity and on the self-stimulation paradigm were completely reversed by pre-treatment with the CB1 receptor antagonist AM-251. These findings indicate that the administration of AMG-3 to rats elicits a specific behavioral profile, most probably associated with the activation of CB1 receptors and without effects indicating abuse potential.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-hydroxy-4-(1,1-dimethylheptyl)p...,
http://linkedlifedata.com/resource/pubmed/chemical/AM 251,
http://linkedlifedata.com/resource/pubmed/chemical/AMG 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanols,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0955-8810
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
499-510
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| pubmed:dateRevised |
2009-7-7
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| pubmed:meshHeading |
pubmed-meshheading:16148456-Animals,
pubmed-meshheading:16148456-Behavior, Animal,
pubmed-meshheading:16148456-Binding, Competitive,
pubmed-meshheading:16148456-Cannabinoids,
pubmed-meshheading:16148456-Catalepsy,
pubmed-meshheading:16148456-Cell Membrane,
pubmed-meshheading:16148456-Cerebral Cortex,
pubmed-meshheading:16148456-Cyclohexanols,
pubmed-meshheading:16148456-Dose-Response Relationship, Drug,
pubmed-meshheading:16148456-Male,
pubmed-meshheading:16148456-Molecular Structure,
pubmed-meshheading:16148456-Motor Activity,
pubmed-meshheading:16148456-Pain,
pubmed-meshheading:16148456-Pain Measurement,
pubmed-meshheading:16148456-Piperidines,
pubmed-meshheading:16148456-Pyrazoles,
pubmed-meshheading:16148456-Rats,
pubmed-meshheading:16148456-Rats, Sprague-Dawley,
pubmed-meshheading:16148456-Receptor, Cannabinoid, CB1,
pubmed-meshheading:16148456-Time Factors,
pubmed-meshheading:16148456-Tritium
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| pubmed:year |
2005
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| pubmed:articleTitle |
Behavioral pharmacological properties of a novel cannabinoid 1',1'-dithiolane delta8-THC analog, AMG-3.
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| pubmed:affiliation |
Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece. kantoniu@cc.uoi.gr
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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