|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0033414,
umls-concept:C0039194,
umls-concept:C0041361,
umls-concept:C0085358,
umls-concept:C0546816,
umls-concept:C1332397,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1420812,
umls-concept:C1705180,
umls-concept:C1706438,
umls-concept:C2698600
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2005-9-8
|
|
pubmed:abstractText |
The molecular signals that allow primed CD8 T cells to persist and be effective are particularly important during cancer growth. With response to tumor-expressed Ag following adoptive T cell transfer, we show that CD8 effector cells deficient in OX40, a TNFR family member, could not mediate short-term tumor suppression. OX40 was required at two critical stages. The first was during CD8 priming in vitro, in which APC-transmitted OX40 signals endowed the ability to survive when adoptively transferred in vivo before tumor Ag encounter. The second was during the in vivo recall response of primed CD8 T cells, the stage in which OX40 contributed to the further survival and accumulation of T cells at the tumor site. The lack of OX40 costimulation was associated with reduced levels of Bcl-x(L), and retroviral expression of Bcl-x(L) in tumor-reactive CD8 T cells conferred greatly enhanced tumor protection following adoptive transfer. These data demonstrate that OX40 and Bcl-x(L) can control survival of primed CD8 T cells and provide new insights into both regulation of CD8 immunity and control of tumors.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Bcl2l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Taa1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
175
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3534-41
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16148096-Animals,
pubmed-meshheading:16148096-Antigens, Neoplasm,
pubmed-meshheading:16148096-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16148096-Cell Adhesion Molecules,
pubmed-meshheading:16148096-Cell Survival,
pubmed-meshheading:16148096-Cells, Cultured,
pubmed-meshheading:16148096-Gene Expression Regulation,
pubmed-meshheading:16148096-Immunologic Memory,
pubmed-meshheading:16148096-Immunotherapy, Adoptive,
pubmed-meshheading:16148096-Mice,
pubmed-meshheading:16148096-Mice, Inbred C57BL,
pubmed-meshheading:16148096-Mice, Transgenic,
pubmed-meshheading:16148096-Neoplasm Proteins,
pubmed-meshheading:16148096-Neoplasms, Experimental,
pubmed-meshheading:16148096-Receptors, OX40,
pubmed-meshheading:16148096-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16148096-bcl-X Protein
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen.
|
|
pubmed:affiliation |
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
