Source:http://linkedlifedata.com/resource/pubmed/id/16147897
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-9-8
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pubmed:abstractText |
Recent studies have shown the gene expression of several transporters to be circadian rhythmic. However, it remains to be elucidated whether the expression of P-glycoprotein, which is involved in the transport of many medications, undergoes 24 h rhythmicity. To address this issue, we investigated daily profiles of P-glycoprotein mRNA and protein levels in peripheral mouse tissues. In the liver and intestine, but not in the kidney, Abcb1a mRNA expression showed clear 24 h rhythmicity. On the other hand, Abcb1b and Abcb4, the other P-glycoprotein genes, did not exhibit significant rhythmic expression in the studied tissues. In the intestine, levels of whole P-glycoprotein also exhibited a daily rhythm, with a peak occurring in the latter half of the light phase and a trough at the onset of the light phase. Consistent with the day-night change of P-glycoprotein level, the ex vivo accumulation of digoxin, an Abcb1a P-glycoprotein substrate, into the intestinal segments at the onset of dark phase was significantly lower than it was at the onset of the light phase. Thus, Abcb1a P-glycoprotein expression, and apparently its function, are 24 h rhythmic at least in mouse intestine tissue. This circadian variation might be involved in various chronopharmacological phenomena.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0742-0528
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
655-65
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pubmed:meshHeading |
pubmed-meshheading:16147897-Animals,
pubmed-meshheading:16147897-Circadian Rhythm,
pubmed-meshheading:16147897-Digoxin,
pubmed-meshheading:16147897-Gene Expression Regulation,
pubmed-meshheading:16147897-Jejunum,
pubmed-meshheading:16147897-Kidney,
pubmed-meshheading:16147897-Liver,
pubmed-meshheading:16147897-Male,
pubmed-meshheading:16147897-Mice,
pubmed-meshheading:16147897-Mice, Inbred C57BL,
pubmed-meshheading:16147897-P-Glycoproteins,
pubmed-meshheading:16147897-RNA, Messenger,
pubmed-meshheading:16147897-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
Daily rhythms of P-glycoprotein expression in mice.
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pubmed:affiliation |
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical School, Minami-kawachi, Tochigi, Japan.
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pubmed:publicationType |
Journal Article
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