Linked Life Data

16146750

Source:http://linkedlifedata.com/resource/pubmed/id/16146750

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-9-8
pubmed:abstractText
It has long been recognized that major trauma, shock, or burn injury can lead to an acute systemic inflammatory state (SIRS) as well as the multiple organ dysfunction syndrome (MODS). Because of the high mortality rate associated with the development of MODS, for over two decades an intense effort has been devoted towards trying to unravel the underlying mechanisms of this complex syndrome. Although the gut has been implicated in the development of SIRS and MODS experimentally and clinically, its exact role in the pathogenesis of SIRS and MODS remains controversial. However, based on recent experimental evidence, it appears that unique gut-derived factors carried in the intestinal lymph, but not the portal vein, lead to acute injury- and shock-induced SIRS and MODS. These observations have led to the gut-lymph hypothesis of MODS, where gut-derived factors present in intestinal (mesenteric) lymph serve as the triggers that initiate the systemic inflammatory and tissue injurious responses observed after major trauma or episodes of shock.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
520-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review.
pubmed:affiliation
Department of Surgery, UMDNJ-New Jersey Medical School, MSB G506, Newark, NJ 07103, USA. edeitch@umdnj.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural