16145542

Source:http://linkedlifedata.com/resource/pubmed/id/16145542

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0025914, umls-concept:C0026809, umls-concept:C0035499, umls-concept:C0035668, umls-concept:C0080125, umls-concept:C0086022, umls-concept:C0442335, umls-concept:C0449445, umls-concept:C0559956, umls-concept:C1412056, umls-concept:C1705099
pubmed:dateCreated	2005-9-7
pubmed:abstractText	To develop a hammerhead ribozymes (Rz) that might be exploited in a "digest and replace" gene therapy strategy for autosomal dominant retinitis pigmentosa (ADRP) caused by mutations in the gene for rhodopsin (RHO).
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 EY11596
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9605351
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/RNA, Catalytic, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Rhodopsin, http://linkedlifedata.com/resource/pubmed/chemical/Rod Opsins, http://linkedlifedata.com/resource/pubmed/chemical/hammerhead ribozyme
pubmed:status	MEDLINE
pubmed:issn	1090-0535
pubmed:author	pubmed-author:GorbatyukM SMS, pubmed-author:HauswirthWilliam WWW, pubmed-author:LewinAlfred SAS, pubmed-author:PangJ JJJ, pubmed-author:ThomasJJJr
pubmed:issnType	Electronic
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	648-56
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:16145542-Animals, pubmed-meshheading:16145542-Blotting, Western, pubmed-meshheading:16145542-Cells, Cultured, pubmed-meshheading:16145542-Dependovirus, pubmed-meshheading:16145542-Electroretinography, pubmed-meshheading:16145542-Gene Therapy, pubmed-meshheading:16145542-Genetic Vectors, pubmed-meshheading:16145542-Immunohistochemistry, pubmed-meshheading:16145542-In Situ Hybridization, pubmed-meshheading:16145542-Kidney, pubmed-meshheading:16145542-Mice, pubmed-meshheading:16145542-Mice, Inbred C57BL, pubmed-meshheading:16145542-Mice, Knockout, pubmed-meshheading:16145542-RNA, Catalytic, pubmed-meshheading:16145542-RNA, Messenger, pubmed-meshheading:16145542-Retinitis Pigmentosa, pubmed-meshheading:16145542-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16145542-Rhodopsin, pubmed-meshheading:16145542-Rod Opsins, pubmed-meshheading:16145542-Transfection
pubmed:year	2005
pubmed:articleTitle	Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach.
pubmed:affiliation	Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA. mari653@ufl.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural