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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-10-24
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pubmed:abstractText |
We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3beta (GSK-3beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
390
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16143450-Analysis of Variance,
pubmed-meshheading:16143450-Animals,
pubmed-meshheading:16143450-Blotting, Western,
pubmed-meshheading:16143450-Dose-Response Relationship, Radiation,
pubmed-meshheading:16143450-Electroshock,
pubmed-meshheading:16143450-Enzyme Activation,
pubmed-meshheading:16143450-Frontal Lobe,
pubmed-meshheading:16143450-Gene Expression Regulation,
pubmed-meshheading:16143450-Male,
pubmed-meshheading:16143450-Phosphoprotein Phosphatases,
pubmed-meshheading:16143450-Phosphorylation,
pubmed-meshheading:16143450-Protein Kinases,
pubmed-meshheading:16143450-Protein Phosphatase 2,
pubmed-meshheading:16143450-Rats,
pubmed-meshheading:16143450-Rats, Sprague-Dawley,
pubmed-meshheading:16143450-Serine,
pubmed-meshheading:16143450-Threonine,
pubmed-meshheading:16143450-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex.
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pubmed:affiliation |
Department of Psychiatry & Behavioral Science, Seoul National University College of Medicine, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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