|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002092,
umls-concept:C0004048,
umls-concept:C0004096,
umls-concept:C0034656,
umls-concept:C0205087,
umls-concept:C0205210,
umls-concept:C0231491,
umls-concept:C0443286,
umls-concept:C0547040,
umls-concept:C0599946,
umls-concept:C0805586,
umls-concept:C1566067
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-3-27
|
|
pubmed:abstractText |
Asthma is characterized by increased recruitment of inflammatory cells from the circulation into the airways. As selectins mediate tethering and rolling of leukocytes on the vascular endothelium, they constitute a promising target for the therapeutic modulation of inflammation. We evaluated the effect of inhaled bimosiamose (TBC1269), a synthetic pan-selectin antagonist, on allergen-induced late asthmatic reactions (LAR) in mild asthmatics.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1094-5539
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
233-41
|
|
pubmed:meshHeading |
pubmed-meshheading:16140027-Administration, Inhalation,
pubmed-meshheading:16140027-Adult,
pubmed-meshheading:16140027-Allergens,
pubmed-meshheading:16140027-Anti-Asthmatic Agents,
pubmed-meshheading:16140027-Asthma,
pubmed-meshheading:16140027-Breath Tests,
pubmed-meshheading:16140027-Bronchial Provocation Tests,
pubmed-meshheading:16140027-Cross-Over Studies,
pubmed-meshheading:16140027-Double-Blind Method,
pubmed-meshheading:16140027-Forced Expiratory Volume,
pubmed-meshheading:16140027-Hexanes,
pubmed-meshheading:16140027-Humans,
pubmed-meshheading:16140027-Leukocyte Count,
pubmed-meshheading:16140027-Lymphocyte Count,
pubmed-meshheading:16140027-Male,
pubmed-meshheading:16140027-Mannose,
pubmed-meshheading:16140027-Methacholine Chloride,
pubmed-meshheading:16140027-Nitric Oxide,
pubmed-meshheading:16140027-Treatment Outcome
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial.
|
|
pubmed:affiliation |
Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany. k.beeh@insaf-wi.de
|
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
