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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-9-7
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pubmed:abstractText |
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0887-4476
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pubmed:author |
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pubmed:copyrightInfo |
Synapse 58:211-214, 2005. (c) 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16138319-Amphetamine,
pubmed-meshheading:16138319-Amphetamine-Related Disorders,
pubmed-meshheading:16138319-Animals,
pubmed-meshheading:16138319-Disease Models, Animal,
pubmed-meshheading:16138319-Dopamine,
pubmed-meshheading:16138319-Dopamine Uptake Inhibitors,
pubmed-meshheading:16138319-Environment,
pubmed-meshheading:16138319-Extracellular Fluid,
pubmed-meshheading:16138319-Food Deprivation,
pubmed-meshheading:16138319-Genetic Predisposition to Disease,
pubmed-meshheading:16138319-Genotype,
pubmed-meshheading:16138319-Impulsive Behavior,
pubmed-meshheading:16138319-Male,
pubmed-meshheading:16138319-Mice,
pubmed-meshheading:16138319-Mice, Inbred DBA,
pubmed-meshheading:16138319-Microdialysis,
pubmed-meshheading:16138319-Nucleus Accumbens,
pubmed-meshheading:16138319-Reward,
pubmed-meshheading:16138319-Sodium Channel Blockers,
pubmed-meshheading:16138319-Synaptic Transmission,
pubmed-meshheading:16138319-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Environment makes amphetamine-induced dopamine release in the nucleus accumbens totally impulse-dependent.
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pubmed:affiliation |
Dipartimento di Psicologia, Università "La Sapienza," and Fondazione Santa Lucia IRCCS, Rome, Italy. rossella.ventura@uniroma1.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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