Linked Life Data

1613548

Source:http://linkedlifedata.com/resource/pubmed/id/1613548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-7-30
pubmed:abstractText
Tachykinin peptides are distributed widely in the nervous system and have been shown to play a prominent role in nociceptive pathways in the spinal cord and dorsal root ganglia. This study investigated the inflammation-induced response of dorsal horn projection neurons and local circuit neurons expressing preprotachykinin (PPT) mRNA using RNA blot analysis and in situ hybridization histochemistry. To identify projection neurons, fluorogold was injected into the parabrachial area of the brainstem. In laminae I, II and V/VI ipsilateral to inflammation, there was a differential increase in the number of neurons exhibiting PPT mRNA. In lamina I, the number of spinal projection neurons containing PPT mRNA showed a greater than 200% increase. The identification of spinal projection neurons with inflammation-induced increases in PPT mRNA suggests that tachykinin peptides may act as neurotransmitters in nociceptive CNS projection pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2563-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Gene regulation in an ascending nociceptive pathway: inflammation-induced increase in preprotachykinin mRNA in rat lamina I spinal projection neurons.
pubmed:affiliation
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article