Source:http://linkedlifedata.com/resource/pubmed/id/16135084
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-11-7
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| pubmed:abstractText |
The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection. Such an amphiphilic nitrone protected human neuroblastoma cells at low micromolar concentrations against oxidative damage and death induced by exposure to the beta-amyloid peptide, hydrogen peroxide and 3-hydroxykynurenine. Daily administration of the antioxidant at a concentration of only 5 mum significantly increased the lifespan of the individually cultured rotifer Philodina acuticornis odiosa Milne. This compound is unique in its exceptional anti-ageing efficacy, being one order of magnitude more potent than any other compound previously tested on rotifers. The nitrone protected these aquatic animals against the lethal toxicity of hydrogen peroxide and doxorubicin and greatly enhanced their survival when co-administered with these oxidotoxins. These findings indicate that amphiphilic antioxidants have a great potential as neuroprotective agents in preventing the death of cells and organisms exposed to enhanced oxidative stress and damage.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Disaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Imines,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/nitrones
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
0022-3042
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
962-73
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16135084-Aging,
pubmed-meshheading:16135084-Amyloid beta-Peptides,
pubmed-meshheading:16135084-Animals,
pubmed-meshheading:16135084-Cell Line, Tumor,
pubmed-meshheading:16135084-Cell Survival,
pubmed-meshheading:16135084-Diagnostic Imaging,
pubmed-meshheading:16135084-Disaccharides,
pubmed-meshheading:16135084-Disease Models, Animal,
pubmed-meshheading:16135084-Dose-Response Relationship, Drug,
pubmed-meshheading:16135084-Drug Interactions,
pubmed-meshheading:16135084-Humans,
pubmed-meshheading:16135084-Hydrogen Peroxide,
pubmed-meshheading:16135084-Imines,
pubmed-meshheading:16135084-Life Expectancy,
pubmed-meshheading:16135084-Mitochondrial Diseases,
pubmed-meshheading:16135084-Neuroblastoma,
pubmed-meshheading:16135084-Neuroprotective Agents,
pubmed-meshheading:16135084-Nitrogen Oxides,
pubmed-meshheading:16135084-Oxidative Stress,
pubmed-meshheading:16135084-Rotifera
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| pubmed:year |
2005
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| pubmed:articleTitle |
Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.
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| pubmed:affiliation |
Abteilung fuer Stoffwechselphysiologie, Institut fuer Zoologie, Anthropologie und Entwicklungsbiologie der Georg August Universitaet Goettingen, Goettingen, Germany. bpoegge@gwdg.de
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|