|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0032961,
umls-concept:C0042149,
umls-concept:C0079189,
umls-concept:C0086418,
umls-concept:C0205210,
umls-concept:C0205217,
umls-concept:C0205262,
umls-concept:C0231174,
umls-concept:C0392756,
umls-concept:C0456603,
umls-concept:C1416433,
umls-concept:C1423842,
umls-concept:C1527178,
umls-concept:C1564138
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-9-1
|
|
pubmed:abstractText |
Indoleamine 2,3-dioxygenase (IDO) expression in fetal trophoblast and decidual antigen-presenting cells has been proposed to inactivate maternal T cells and thereby prevent rejection of the "fetal allograft" in early pregnancy. Psychic stress has been proposed to cause miscarriages as well as infertility, at the same time in pregnancy when blockade of IDO causes loss, but the suggested mechanism of stress-triggered loss has been an increased ratio of pro-rejection Th1-type cytokines to anti-rejection Th2/3 cytokines. Could stress act by reducing IDO expression?
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1046-7408
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
203-16
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16135011-Abortion, Induced,
pubmed-meshheading:16135011-Abortion, Spontaneous,
pubmed-meshheading:16135011-Animals,
pubmed-meshheading:16135011-Cytokines,
pubmed-meshheading:16135011-Female,
pubmed-meshheading:16135011-Humans,
pubmed-meshheading:16135011-Immunohistochemistry,
pubmed-meshheading:16135011-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:16135011-Keratins,
pubmed-meshheading:16135011-Lymphocyte Count,
pubmed-meshheading:16135011-Male,
pubmed-meshheading:16135011-Mice,
pubmed-meshheading:16135011-Mice, Inbred A,
pubmed-meshheading:16135011-Mice, Inbred DBA,
pubmed-meshheading:16135011-Pregnancy,
pubmed-meshheading:16135011-Th1 Cells,
pubmed-meshheading:16135011-Th2 Cells,
pubmed-meshheading:16135011-Uterus
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans.
|
|
pubmed:affiliation |
Biomedical Research Center, Charité, University Medicine of Berlin, Berlin, Germany. clarkd@mcmaster.ca
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
