Linked Life Data

16131354

Source:http://linkedlifedata.com/resource/pubmed/id/16131354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9 Suppl
pubmed:dateCreated
2005-8-31
pubmed:abstractText
The stem cell is an essential component of a developmental phenomenon-one of the key components of a program fundamental to organogenesis and the maintenance of homeostasis throughout life. The stem cell confers plasticity to the process. Because aging is part of the developmental arc, an understanding of the stem cell is essential to understanding aging and some of the degenerative conditions that accompany it. Because stem cells may be isolated and manipulated ex vivo and then reimplanted into organs, they may serve a variety of functions. They have the capability of migrating long distances and targeting pathological conditions, of expressing therapeutic genes and responding to cues that shift their differentiation toward deficient lineages. Therefore, stem cells may be used for cell replacement, for therapeutic interventions, and potentially to modify aging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-8614
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S287-91
pubmed:dateRevised
2008-3-10
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
A role for stem cell biology in the physiological and pathological aspects of aging.
pubmed:affiliation
Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. esnyder@burnham.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't