| pubmed-article:1612748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0243026 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1612748 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:1612748 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1612748 | pubmed:dateCreated | 1992-7-24 | lld:pubmed |
| pubmed-article:1612748 | pubmed:abstractText | Because of its neutrophil-activating properties, interleukin-8 (IL-8) may play an important role in the pathophysiology of sepsis. We measured circulating IL-8 levels in 47 patients with clinical sepsis. Levels on admission were elevated in 42 of the 47 patients (89%) and were comparable in patients with gram-positive or gram-negative infections. Patients with shock had significantly higher IL-8 levels than normotensive patients (P = 0.0014, Wilcoxon-Mann-Whitney test), whereas no differences in IL-8 levels were found between patients with or without adult respiratory distress syndrome. Patients who died had higher IL-8 levels on admission than the patients who survived. The largest differences in IL-8 levels between survivors and nonsurvivors was found when only patients with positive cultures were considered (P = 0.0342). IL-8 levels appeared to correlate significantly with lactate levels and inversely with leukocyte and platelet numbers and mean arterial pressure. In addition, the IL-8 level in the sepsis patients was found to correlate significantly with levels of IL-6, elastase-alpha 1-antitrypsin, and C3a. Serial observations revealed that in most patients IL-8 levels decreased, irrespective of the outcome. Thus, our results demonstrate that IL-8 levels are increased in most patients with sepsis and correlate with some important clinical, biochemical, and inflammatory parameters. These findings suggest a role for IL-8 in the pathophysiology of sepsis. | lld:pubmed |
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| pubmed-article:1612748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1612748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1612748 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1612748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1612748 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1612748 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:AardenL ALA | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:ThijsL GLG | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:HartMM | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:HackC ECE | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:NuijensJ HJH | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:EerenbergA... | lld:pubmed |
| pubmed-article:1612748 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:1612748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1612748 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:1612748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1612748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1612748 | pubmed:pagination | 2835-42 | lld:pubmed |
| pubmed-article:1612748 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1612748 | pubmed:meshHeading | pubmed-meshheading:1612748-... | lld:pubmed |
| pubmed-article:1612748 | pubmed:meshHeading | pubmed-meshheading:1612748-... | lld:pubmed |
| pubmed-article:1612748 | pubmed:meshHeading | pubmed-meshheading:1612748-... | lld:pubmed |
| pubmed-article:1612748 | pubmed:meshHeading | pubmed-meshheading:1612748-... | lld:pubmed |
