Linked Life Data

16125765

Source:http://linkedlifedata.com/resource/pubmed/id/16125765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2005-9-5
pubmed:abstractText
The metals Mn, Fe, Cu, and Zn, and the non-metal Se are considered "trace elements" (TE) because of their essentiality and very limited quantity in humans. The biological activities of Cu, Fe, Mn, and Se are strongly associated with the presence of unpaired electrons that allow their participation in redox reactions. In biological systems these metals are mostly bound to proteins, forming metalloproteins. Many of the metals in metalloproteins are part of enzymatic systems, have structural and storage functions, or use the protein to be transported to their target site in the organism. In humans Mn, Fe, Cu, Zn, and Se accomplish decisive functions to maintain human health. Deficiency in any of these TE leads to undesirable pathological conditions that can be prevented or reversed by adequate supplementation. In sufficiently nourished persons, supplementation should be carefully controlled, given the toxic effects ascribed to TE when present in quantities exceeding those required for accomplishing their biological functions. The dietary reference intakes provided by national regulatory agencies are guides to define intake, supplementation and toxicity of Mn, Fe, Cu, Zn, and Se, as well other elements considered micronutrients for humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-2997
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-44
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Relevance, essentiality and toxicity of trace elements in human health.
pubmed:affiliation
Department of Nutrition, University of California, Davis, CA 95616, USA. cgfraga@ucdavis.edu
pubmed:publicationType
Journal Article, Review