Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2005-12-5
pubmed:abstractText
Although anecdotal and correlational results have suggested a reliable relationship between creativity and psychosis, few studies have examined this relationship using empirical methods. In addition, little is known about the neural substrates of creative thinking. We investigated the creative thinking process in relation to schizotypal personality, schizophrenia and prefrontal hemispheric laterality using behavioral and near-infrared optical spectroscopy (NIRS) methods. Schizophrenic, psychometrically ascertained schizotypal, and healthy control subjects (all right-handed) participated in a novel "alternate uses" task designed to assess divergent thinking (DT) ability. The DT task required subjects to generate "uses" for conventional and ambiguous objects. Prefrontal activity was measured using NIRS while subjects were engaged in DT vs. a cognitive control task in a subset of the subjects. Behavioral data indicated that schizotypes had enhanced DT ability compared with schizophrenic and control subjects, who showed similar performance overall. NIRS data showed that DT was associated with bilateral prefrontal cortex (PFC) activation, but the right PFC particularly contributed to the enhanced creative thinking in psychometric schizotypes compared with the other two groups. Thus, creative thinking seems to robustly recruit bilateral PFC, but it is the right PFC that is preferentially activated in schizotypes in relation to their enhanced DT.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-10415133, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-10689061, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-10928739, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-10978688, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-1111477, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-11244378, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-11439239, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-11529423, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-11737792, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-12027399, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-1446212, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-14472013, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-14561447, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-15050579, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-15158012, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-15172131, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-15513084, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-15513206, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-1805349, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-2769245, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-2880393, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-3574663, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-3584671, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-3746261, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-4453488, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-4708123, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-4814805, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-5525825, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-6395909, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-6725009, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-7162920, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-7165477, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-7165478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-7410706, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-7775222, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-8110913, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-8753882, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-8771226, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-8978440, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-9000315, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-912236, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-9148195, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-9519066, http://linkedlifedata.com/resource/pubmed/commentcorrection/16125369-9743549
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0920-9964
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-82
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: a behavioral and near-infrared optical imaging study.
pubmed:affiliation
Department of Psychology, Wilson Hall, Vanderbilt University 111, 21st Ave S, Nashville TN 37240, USA. brad.folley@vanderbilt.edu
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