| pubmed-article:16110513 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C0076088 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C0460005 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C1705994 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16110513 | lifeskim:mentions | umls-concept:C1513492 | lld:lifeskim |
| pubmed-article:16110513 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16110513 | pubmed:dateCreated | 2005-10-24 | lld:pubmed |
| pubmed-article:16110513 | pubmed:abstractText | Motor axons in the trunk of the developing zebrafish exit from the ventral spinal cord in one ventral root per hemisegment and grow on a common path toward the region of the horizontal myoseptum, where they select their specific pathways. Tenascin-C, a component of the extracellular matrix, is concentrated in this choice region. Adaxial cells and other myotomal cells express tenascin-C mRNA, suggesting that these cells are the source of tenascin-C protein. Overexpressing an axon repellent fragment containing the cysteine-rich region and the epidermal growth factor-like repeats of tenascin-C led to retarded growth of ventral motor nerves between their spinal exit point and the horizontal myoseptum. Injection of a protein fragment containing the same part of tenascin-C also induced slower growth of motor nerves. Conversely, knock down of tenascin-C protein resulted in abnormal lateral branching of ventral motor nerves. In the zebrafish unplugged mutant, in which axons display pathfinding defects in the region of the horizontal myoseptum, tenascin-C immunoreactivity was not detectable in this region, indicating an abnormal extracellular matrix in unplugged. We conclude that tenascin-C is part of a specialized extracellular matrix in the region of the horizontal myoseptum that influences the growth of motor axons. | lld:pubmed |
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| pubmed-article:16110513 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16110513 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16110513 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16110513 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16110513 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16110513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16110513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16110513 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16110513 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16110513 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:SchachnerMeli... | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:BeckerCatheri... | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:BeckerThomasT | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:GranatoMichae... | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:SchweitzerJör... | lld:pubmed |
| pubmed-article:16110513 | pubmed:author | pubmed-author:LefebvreJulie... | lld:pubmed |
| pubmed-article:16110513 | pubmed:copyrightInfo | Developmental Dynamics 234:550-566, 2005. (c) 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:16110513 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16110513 | pubmed:volume | 234 | lld:pubmed |
| pubmed-article:16110513 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16110513 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16110513 | pubmed:pagination | 550-66 | lld:pubmed |
| pubmed-article:16110513 | pubmed:dateRevised | 2011-1-14 | lld:pubmed |
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| pubmed-article:16110513 | pubmed:meshHeading | pubmed-meshheading:16110513... | lld:pubmed |
| pubmed-article:16110513 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16110513 | pubmed:articleTitle | Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish. | lld:pubmed |
| pubmed-article:16110513 | pubmed:affiliation | Zentrum für Molekulare Neurobiologie, Hamburg, Germany. | lld:pubmed |
| pubmed-article:16110513 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16110513 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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