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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
2006-3-13
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pubmed:abstractText |
Obesity and Type 2 diabetes have become epidemics in the Western world. Understanding the pathophysiology of the disease should help in prevention and treatment of these disorders. A common theme is the presence of insulin resistance that eventually results in Type 2 diabetes. To understand the underlying mechanisms in the progression of the disease states, investigators have created mouse models by transgenic overexpression of a candidate gene or produced gene-deletion mouse models. This review will summarize many of the more appropriate models that study insulin resistance and Type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lox protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Lysine 6-Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
1357-2725
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
904-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16103004-Adolescent,
pubmed-meshheading:16103004-Animals,
pubmed-meshheading:16103004-Diabetes Mellitus, Lipoatrophic,
pubmed-meshheading:16103004-Diabetes Mellitus, Type 2,
pubmed-meshheading:16103004-Disease Models, Animal,
pubmed-meshheading:16103004-Extracellular Matrix Proteins,
pubmed-meshheading:16103004-Humans,
pubmed-meshheading:16103004-Insulin,
pubmed-meshheading:16103004-Insulin Receptor Substrate Proteins,
pubmed-meshheading:16103004-Insulin Resistance,
pubmed-meshheading:16103004-Insulin-Secreting Cells,
pubmed-meshheading:16103004-Integrases,
pubmed-meshheading:16103004-Mice,
pubmed-meshheading:16103004-Mice, Knockout,
pubmed-meshheading:16103004-Phosphoproteins,
pubmed-meshheading:16103004-Protein-Lysine 6-Oxidase,
pubmed-meshheading:16103004-Receptor, IGF Type 1,
pubmed-meshheading:16103004-Receptor, Insulin,
pubmed-meshheading:16103004-Viral Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Mouse models created to study the pathophysiology of Type 2 diabetes.
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pubmed:affiliation |
Diabetes Branch, National Institutes of Health, Room 8D12, Building 10, Bethesda, MD 20892-1758, USA. derek@helix.nih.gov
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pubmed:publicationType |
Journal Article,
Review
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