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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2005-8-29
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pubmed:abstractText |
The small G protein Rheb (Ras homologue enriched in brain) is known to promote mammalian target of rapamycin (mTOR) signaling. In this study, we show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal and that tuberous sclerosis complex-1 (TSC) and TSC2 impairs RhebL1-mediated signaling through mTOR. We identify critical residues within the switch I region (N41) and 'constitutive' effector (Ec) region (Y/F54 and L56) of Rheb and RhebL1, which are required for their efficient activation of mTOR signaling. Mutation of Rheb and RhebL1 at N41 impaired their interaction with mTOR, which identifies mTOR as a common downstream target of both Rheb and RhebL1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RHEB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 2 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
579
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4763-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16098514-Amino Acid Sequence,
pubmed-meshheading:16098514-Cell Line,
pubmed-meshheading:16098514-Humans,
pubmed-meshheading:16098514-Molecular Sequence Data,
pubmed-meshheading:16098514-Monomeric GTP-Binding Proteins,
pubmed-meshheading:16098514-Neuropeptides,
pubmed-meshheading:16098514-Protein Kinases,
pubmed-meshheading:16098514-Repressor Proteins,
pubmed-meshheading:16098514-Sequence Alignment,
pubmed-meshheading:16098514-Signal Transduction,
pubmed-meshheading:16098514-TOR Serine-Threonine Kinases,
pubmed-meshheading:16098514-Tumor Suppressor Proteins,
pubmed-meshheading:16098514-ras Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
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pubmed:affiliation |
University of Dundee, Medical Sciences Institute/Wellcome Building Complex, Dow Street, Dundee DD1 5EH, UK. a.r.tee@dundee.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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