Linked Life Data

16097483

Source:http://linkedlifedata.com/resource/pubmed/id/16097483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2005-8-15
pubmed:abstractText
The role of the mammalian cerebellum ranges from motor coordination, sensory-motor integration, motor learning, and timing to nonmotor functions such as cognition. In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development of the cerebellar cortical circuitry closely parallels motor coordination. Ultrastructural analysis of the morphological development of the cerebellar circuitry, coupled with the temporal and spatial identification of the neurochemical substrates expressed during development, will help to elucidate their roles in the establishment of the cerebellar circuitry and hence motor activity. Furthermore, the convenience of a number of naturally occurring mouse mutations has allowed a functional dissection of the various cellular elements that make up the cerebellar circuitry. This understanding will also help in the approach to possible therapies of pathologies arising during development because the cerebellum is especially prone to such perturbation because of its late development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
2090-5904
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-60; discussion 263-72
pubmed:dateRevised
2011-2-23
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Cerebellar development and plasticity: perspectives for motor coordination strategies, for motor skills, and for therapy.
pubmed:affiliation
Laboratory for Stress Neurobiology, 409 Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Review