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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-20
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pubmed:abstractText |
The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0143-3334
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pubmed:author |
pubmed-author:BadiiGG,
pubmed-author:BoufflerS DSD,
pubmed-author:CostesLL,
pubmed-author:CoxRR,
pubmed-author:DarakhshanFF,
pubmed-author:EdwardsA AAA,
pubmed-author:FinnonPP,
pubmed-author:FinnonRR,
pubmed-author:MoodyJJ,
pubmed-author:SkidmoreC JCJ,
pubmed-author:SzluinskaMM,
pubmed-author:UllrichRR,
pubmed-author:YoshidaKK
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16093251-Acute Disease,
pubmed-meshheading:16093251-Animals,
pubmed-meshheading:16093251-Carrier Proteins,
pubmed-meshheading:16093251-Chromosome Mapping,
pubmed-meshheading:16093251-Endpoint Determination,
pubmed-meshheading:16093251-Genetic Markers,
pubmed-meshheading:16093251-Genetic Predisposition to Disease,
pubmed-meshheading:16093251-Inheritance Patterns,
pubmed-meshheading:16093251-Leukemia, Myeloid,
pubmed-meshheading:16093251-Leukemia, Radiation-Induced,
pubmed-meshheading:16093251-Mice,
pubmed-meshheading:16093251-Mice, Inbred C57BL,
pubmed-meshheading:16093251-Mice, Inbred CBA,
pubmed-meshheading:16093251-Microsatellite Repeats,
pubmed-meshheading:16093251-Multigene Family,
pubmed-meshheading:16093251-Nuclear Proteins,
pubmed-meshheading:16093251-Phenotype,
pubmed-meshheading:16093251-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
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pubmed:affiliation |
Radiation Effects Department, Health Protection Agency, Radiation Protection Division, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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