Source:http://linkedlifedata.com/resource/pubmed/id/16087337
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
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| pubmed:dateCreated |
2005-8-22
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| pubmed:abstractText |
The 2-arylvinyl moiety in 1-(3-chlorophenyl)-3-(4-piperidyl)-5-[(E)-2-(5-chloro-1H-indol-3-yl)vinyl]pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, was transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. Many of the 5-[(E)-2-arylvinyl]pyrazoles synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates of gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4299-303
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| pubmed:meshHeading |
pubmed-meshheading:16087337-Anti-Bacterial Agents,
pubmed-meshheading:16087337-DNA Gyrase,
pubmed-meshheading:16087337-Drug Resistance,
pubmed-meshheading:16087337-Gram-Positive Bacteria,
pubmed-meshheading:16087337-Microbial Sensitivity Tests,
pubmed-meshheading:16087337-Pyrazoles,
pubmed-meshheading:16087337-Quinolones,
pubmed-meshheading:16087337-Structure-Activity Relationship
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles.
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| pubmed:affiliation |
Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd, 33-94, Enoki, Suita, Osaka 564-0053, Japan. akihiko-tanitame@dainippon-pharm.co.jp
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| pubmed:publicationType |
Journal Article
|