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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-9-13
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pubmed:abstractText |
Tumor-derived immune suppression is considered to be a major mechanism of tumor evasion from the immune system destruction, however, little is known regarding the induction of T-cell functional suppression by tumor-derived exosomes. Herein, we investigate tumor-derived exosomes involved in normal immunological communications as means of inhibiting an antitumor T-cell response. Exosomes derived from LNCaP, a human prostate cancer cell line, were visualized by FACS and identified based on size (80-200 nm) in comparison to marker beads. Exosomes from tumor cell line inhibited T-cell proliferation. Dose-dependent apoptosis of T cells was induced by co-culture with tumor exosomes. Addition of anti-FasL antibody blocked the apoptosis induction by tumor exosomes. This study suggests that induction of T-cell apoptosis by tumor-derived exosomes appears to be a novel mechanism of tumor immune evasion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1079-9796
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16081306-Antigens, Neoplasm,
pubmed-meshheading:16081306-Apoptosis,
pubmed-meshheading:16081306-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16081306-Cell Line, Tumor,
pubmed-meshheading:16081306-Cell Proliferation,
pubmed-meshheading:16081306-Coculture Techniques,
pubmed-meshheading:16081306-Endosomes,
pubmed-meshheading:16081306-Fas Ligand Protein,
pubmed-meshheading:16081306-Humans,
pubmed-meshheading:16081306-Lymphocyte Activation,
pubmed-meshheading:16081306-Male,
pubmed-meshheading:16081306-Membrane Glycoproteins,
pubmed-meshheading:16081306-Prostatic Neoplasms,
pubmed-meshheading:16081306-Tumor Necrosis Factors
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pubmed:articleTitle |
Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis.
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pubmed:affiliation |
London Health Science Centers, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article
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