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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-8-4
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pubmed:abstractText |
A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and micro-positron emission tomography (micro-PET) imaging experiments in rats. Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5096-9
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pubmed:meshHeading |
pubmed-meshheading:16078827-Animals,
pubmed-meshheading:16078827-Brain,
pubmed-meshheading:16078827-Carbon Radioisotopes,
pubmed-meshheading:16078827-Ligands,
pubmed-meshheading:16078827-Positron-Emission Tomography,
pubmed-meshheading:16078827-Quinolines,
pubmed-meshheading:16078827-Radiopharmaceuticals,
pubmed-meshheading:16078827-Rats,
pubmed-meshheading:16078827-Receptors, Metabotropic Glutamate,
pubmed-meshheading:16078827-Structure-Activity Relationship,
pubmed-meshheading:16078827-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone.
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pubmed:affiliation |
Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA. hh285@columbia.edu
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pubmed:publicationType |
Journal Article
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