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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-8-2
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pubmed:abstractText |
CD4+CD25+ regulatory T cells (T reg cells) play a key role in controlling autoimmunity and inflammation. Therefore, therapeutic agents that are capable of elevating numbers or increasing effector functions of this T cell subset are highly desirable. In a previous report we showed that a superagonistic monoclonal antibody specific for rat CD28 (JJ316) expands and activates T reg cells in vivo and upon short-term in vitro culture. Here we demonstrate that application of very low dosages of the CD28 superagonist into normal Lewis rats is sufficient to induce T reg cell expansion in vivo without the generalized lymphocytosis observed with high dosages of JJ316. Single i.v. administration of a low dose of the CD28 superagonist into Dark Agouti (DA) rats or Lewis rats that suffered from experimental autoimmune encephalomyelitis (EAE) proved to be highly and equally efficacious as high-dose treatment. Finally, we show that T reg cells that were isolated from CD28-treated animals displayed enhanced suppressive activity toward myelin basic protein-specific T cells in vitro, and, upon adoptive transfer, protected recipients from EAE. Our data indicate that this class of CD28-specific monoclonal antibodies targets CD4+CD25+ T reg cells and provides a novel means for the effective treatment of multiple sclerosis and other autoimmune diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-10601999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-10795741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-10850488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-10899916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-10899917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11120847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11390435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11466340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11526392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11781358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-11908514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12034883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12086308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12119349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12235217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12391178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12438424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12511873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12522256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12612578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12612581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12616483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12707299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-12864982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-14500627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-14578884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-14734708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15067033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15070759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15117972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15128783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15153463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15235129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15261560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15280421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15308106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15492218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15545984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15696168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-15780990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-7597040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-9022025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16061730-9570536
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
202
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-55
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16061730-Animals,
pubmed-meshheading:16061730-Antibodies, Monoclonal,
pubmed-meshheading:16061730-Antigens, CD28,
pubmed-meshheading:16061730-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16061730-Cell Proliferation,
pubmed-meshheading:16061730-Dose-Response Relationship, Drug,
pubmed-meshheading:16061730-Dose-Response Relationship, Immunologic,
pubmed-meshheading:16061730-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16061730-Immunosuppression,
pubmed-meshheading:16061730-Injections, Intravenous,
pubmed-meshheading:16061730-Lymphocyte Activation,
pubmed-meshheading:16061730-Multiple Sclerosis,
pubmed-meshheading:16061730-Rats,
pubmed-meshheading:16061730-Rats, Inbred Lew,
pubmed-meshheading:16061730-Receptors, Interleukin-2
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pubmed:year |
2005
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pubmed:articleTitle |
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Institute for Virology and Immunobiology, University of Würzburg, D-97078 Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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