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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2005-9-12
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pubmed:abstractText |
Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P>0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P=0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0920-9964
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pubmed:author |
pubmed-author:ChenChiung-MeiCM,
pubmed-author:ChenFen-LinFL,
pubmed-author:ChenI-ChengIC,
pubmed-author:HouYi-TingYT,
pubmed-author:Hsieh-LiHsiu-MeiHM,
pubmed-author:HuangShu-YiSY,
pubmed-author:HungWei-LingWL,
pubmed-author:LaneHsien-YuanHY,
pubmed-author:Lee-ChenGuey-JenGJ,
pubmed-author:LiMing-LiangML,
pubmed-author:LinCheng-YuehCY,
pubmed-author:RoLong-SunLS,
pubmed-author:SoongBing-WenBW,
pubmed-author:SuMing-TsanMT,
pubmed-author:WuYih-RuYR
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
78
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
131-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16054804-Adult,
pubmed-meshheading:16054804-Asian Continental Ancestry Group,
pubmed-meshheading:16054804-Chromosome Mapping,
pubmed-meshheading:16054804-Chromosomes, Human, Pair 6,
pubmed-meshheading:16054804-Female,
pubmed-meshheading:16054804-Humans,
pubmed-meshheading:16054804-Male,
pubmed-meshheading:16054804-Nerve Tissue Proteins,
pubmed-meshheading:16054804-Phosphoprotein Phosphatases,
pubmed-meshheading:16054804-Polymerase Chain Reaction,
pubmed-meshheading:16054804-Polymorphism, Genetic,
pubmed-meshheading:16054804-Protein Phosphatase 2,
pubmed-meshheading:16054804-RNA, Untranslated,
pubmed-meshheading:16054804-Schizophrenia,
pubmed-meshheading:16054804-TATA-Binding Protein Associated Factors,
pubmed-meshheading:16054804-Trinucleotide Repeat Expansion
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pubmed:year |
2005
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pubmed:articleTitle |
Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia.
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pubmed:affiliation |
Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei 105, Taiwan.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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