Linked Life Data

16052979

Source:http://linkedlifedata.com/resource/pubmed/id/16052979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
2005-8-1
pubmed:abstractText
Gastrointestinal stromal tumors (GISTs): clinical and pathological features. The gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. With immunohistochemical, electron microscope and molecular examinations they can be clearly distinguished in both their genotype and phenotype from other mesenchymal tumors. GIST tumors express the CD 117 receptor in more than 90% independent of histopathological features and clinical behaviour. This is why it is considered as the most important characteristic. The incidence is 10-20 new cases per 1 million annually. The number of incidents is expected to increase by the establishment of CD117 and other new markers (protein kinase C theta, DOG1). Nowadays the establishment of the expected biological behavior and malignancy can be difficult. The best prognostic factors are the tumor size and the mitotic index. Dominantly, due to the mutation of the c-kit proto-oncogene and PGDFRA gene that the high level tyrosine kinase activity generates resulting uncontrolled proliferation and cell growth. The imatinib mesylate is a selective inhibitor of the KIT tyrosine kinase receptor and it also blocks the activity of the PDGFRA kinase. The therapeutic consequence of this is that the majority of advanced GIST tumors which do not react to conventional radio- and chemotherapy respond well to tyrosine kinase inhibitor treatment. As a result, survival and patient's quality of life can significantly improve.
pubmed:language
hun
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0030-6002
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1375-81
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16052979-Antineoplastic Agents, pubmed-meshheading:16052979-Enzyme Inhibitors, pubmed-meshheading:16052979-Gastrointestinal Stromal Tumors, pubmed-meshheading:16052979-Humans, pubmed-meshheading:16052979-Immunohistochemistry, pubmed-meshheading:16052979-Membrane Proteins, pubmed-meshheading:16052979-Microscopy, Electron, pubmed-meshheading:16052979-Mitotic Index, pubmed-meshheading:16052979-Mutation, pubmed-meshheading:16052979-Neoplasm Proteins, pubmed-meshheading:16052979-Prognosis, pubmed-meshheading:16052979-Protein Kinase C, pubmed-meshheading:16052979-Protein-Tyrosine Kinases, pubmed-meshheading:16052979-Proto-Oncogene Proteins c-kit, pubmed-meshheading:16052979-Risk Assessment, pubmed-meshheading:16052979-Risk Factors, pubmed-meshheading:16052979-Tumor Markers, Biological
pubmed:year
2005
pubmed:articleTitle
[Gastrointestinal stromal tumors (GISTs): clinical and pathological features].
pubmed:affiliation
Vaszary Kolos Kórhaz, II. Belgyógyászati Osztály, Esztergom. drmarta.kovacs@axelero.hu
pubmed:publicationType
Journal Article, English Abstract, Review