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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL) play in controlling HIV infection. HLA-B63, the serological marker for the closely related HLA-B*1516 and HLA-B*1517 alleles, shares the epitope binding motif of HLA-B57 and HLA-B58, two alleles that have been associated with slow HIV disease progression. We investigated whether HIV-infected individuals who express HLA-B63 generate CTL responses that are comparable in breadth and specificity to those of HLA-B57/58-positive subjects and whether HLA-B63-positive individuals would also present with lower viral set points than the general population. The data show that HLA-B63-positive individuals indeed mounted responses to previously identified HLA-B57-restricted epitopes as well as towards novel, HLA-B63-restricted CTL targets that, in turn, can be presented by HLA-B57 and HLA-B58. HLA-B63-positive subjects generated these responses early in acute HIV infection and were able to control HIV replication in the absence of antiretroviral treatment with a median viral load of 3,280 RNA copies/ml. The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-10358176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-10602880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-10602881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-10694578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-11309482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-11530315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-11543903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-12459592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-12520010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-14685052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-14770175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-14963115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-14963618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-14966520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15067030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15194783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15280502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15286729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15589168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15592417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-15593302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-2038058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-2594067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-8597949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-8638160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-8959245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-9018241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-9029102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16051815-9634482
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:AdamsSharonS,
pubmed-author:AllenTodd MTM,
pubmed-author:AltfeldMarcusM,
pubmed-author:BranderChristianC,
pubmed-author:BrownNancy VNV,
pubmed-author:DaarEric SES,
pubmed-author:FeeneyMargaret EME,
pubmed-author:FrahmNicoleN,
pubmed-author:GoulderPhilip J RPJ,
pubmed-author:HewittHannah SHS,
pubmed-author:KiepielaPhotiniP,
pubmed-author:KorberBetteB,
pubmed-author:LichterfeldMathiasM,
pubmed-author:LindeCaitlyn HCH,
pubmed-author:MarincolaFrancescoF,
pubmed-author:PaeEuniceE,
pubmed-author:RoachTimothyT,
pubmed-author:RosenbergEricE,
pubmed-author:SangoKaoriK,
pubmed-author:St JohnM AnneMA,
pubmed-author:WalkerBruce DBD,
pubmed-author:WurcelAlysse GAG
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10218-25
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16051815-Amino Acid Sequence,
pubmed-meshheading:16051815-Antigen Presentation,
pubmed-meshheading:16051815-Epitopes, T-Lymphocyte,
pubmed-meshheading:16051815-HIV Infections,
pubmed-meshheading:16051815-HLA-B Antigens,
pubmed-meshheading:16051815-Humans,
pubmed-meshheading:16051815-Molecular Sequence Data,
pubmed-meshheading:16051815-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16051815-Viral Load
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pubmed:year |
2005
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pubmed:articleTitle |
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
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pubmed:affiliation |
Partners AIDS Research Center, Massachusetts General Hospital, No. 5214, 149 13th Street, Charlestown, MA 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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