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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-10-20
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pubmed:abstractText |
Donor-derived T cells have been proposed to play a role in pathogenesis of chronic graft-versus-host disease (cGVHD). The impact of ex vivo T-cell depletion (TCD) on cGVHD was analyzed in a randomized multicenter trial involving unrelated donor marrow transplants. A total of 404 patients diagnosed with hematologic malignancies received a total body irradiation-based myeloablative conditioning regimen. GVHD prophylaxis included TCD plus cyclosporine (CSA) or unmodified grafts with CSA plus methotrexate (M/C). Median recipient age was 31.2 years (range, 0.5-55.6 years); median follow-up time since randomization was 4.2 years. The mean number of T cells infused was 1 log lower on the TCD arm. The incidence of cGVHD at 2 years was similar between the TCD and M/C arms, 29% versus 34% (P = .27), respectively. Survival at 3 years from diagnosis of cGVHD was also similar, (TCD 51% versus M/C 58%; P = .29). The proportion of patients with cGVHD who discontinued immunosuppression at 5 years was not different (TCD 72% versus M/C 63%; P = .27), and incidence of serious infections and leukemia relapse were similar on both treatment arms. In spite of a significant reduction of acute GVHD, TCD did not reduce the incidence of cGVHD or improve survival in patients who developed cGVHD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-10204198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-10387937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-10534058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-10845940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11222360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11222394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11319585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11535499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11698275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11719357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11877264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11929759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-11953031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12070007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12091329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12720215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12750699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12786798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-12931120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-13655060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-14625337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-14764530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-15292060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-15730851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-16125590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-1887253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-1912589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-2297567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-2310834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-2653461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-2673331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-7015133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-8429851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-8518176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-9746768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16046530-9845524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:CarterShelly LSL,
pubmed-author:CasperJamesJ,
pubmed-author:GingrichRogerR,
pubmed-author:Henslee-DowneyJeanJ,
pubmed-author:KernanNancy ANA,
pubmed-author:MendizabalAdam MAM,
pubmed-author:National Heart, Lung, and Blood Institute Unrelated Donor Marrow...,
pubmed-author:PapadopoulosEsperanzaE,
pubmed-author:PavleticSteven ZSZ,
pubmed-author:WeisdorfDanielD,
pubmed-author:YanovichSaulS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3308-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16046530-Acute Disease,
pubmed-meshheading:16046530-Adolescent,
pubmed-meshheading:16046530-Adult,
pubmed-meshheading:16046530-Bone Marrow Transplantation,
pubmed-meshheading:16046530-Child,
pubmed-meshheading:16046530-Child, Preschool,
pubmed-meshheading:16046530-Chronic Disease,
pubmed-meshheading:16046530-Graft vs Host Reaction,
pubmed-meshheading:16046530-Humans,
pubmed-meshheading:16046530-Infant,
pubmed-meshheading:16046530-Middle Aged,
pubmed-meshheading:16046530-Prognosis,
pubmed-meshheading:16046530-Survival Rate,
pubmed-meshheading:16046530-T-Lymphocytes,
pubmed-meshheading:16046530-Transplantation, Homologous
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pubmed:year |
2005
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pubmed:articleTitle |
Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation.
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pubmed:affiliation |
University of Nebraska Medical Center, Omaha, USA. pavletis@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Multicenter Study,
Research Support, N.I.H., Extramural
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