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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2005-8-22
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pubmed:abstractText |
A novel diazocan containing dipeptide mimetic was synthesized via reductive N-N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring nitrogen that was used to explore structure-activity relationships in a cell-based assay measuring inhibition of interleukin-1beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BaizeMark WMW,
pubmed-author:BoschGregory KGK,
pubmed-author:DeBiswanathB,
pubmed-author:DemuthThomas PTPJr,
pubmed-author:EllisChristopher DCD,
pubmed-author:FancherAmy NAN,
pubmed-author:LaufersweilerMichael CMC,
pubmed-author:O'NeilSteven VSV,
pubmed-author:OppongKofi AKA,
pubmed-author:SoperDavid LDL,
pubmed-author:SuchanekMaureen KMK,
pubmed-author:WangRichard LRL,
pubmed-author:WangYiliY,
pubmed-author:WosJohn AJA,
pubmed-author:YenPP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4291-4
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pubmed:meshHeading |
pubmed-meshheading:16046125-Caspase 1,
pubmed-meshheading:16046125-Caspases,
pubmed-meshheading:16046125-Dipeptides,
pubmed-meshheading:16046125-Drug Evaluation, Preclinical,
pubmed-meshheading:16046125-Inhibitory Concentration 50,
pubmed-meshheading:16046125-Interleukin-1,
pubmed-meshheading:16046125-Molecular Conformation,
pubmed-meshheading:16046125-Molecular Mimicry,
pubmed-meshheading:16046125-Peptides, Cyclic,
pubmed-meshheading:16046125-Pyrazoles,
pubmed-meshheading:16046125-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.
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pubmed:affiliation |
Procter & Gamble Pharmaceuticals, Inc., 8700 Mason-Montgomery Road, Mason, OH 45040, USA. Oppong.ka@pg.com
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pubmed:publicationType |
Journal Article
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