Source:http://linkedlifedata.com/resource/pubmed/id/16044963
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2005-7-27
|
| pubmed:abstractText |
Second-line chemotherapy with bi-weekly CPT-11 and cisplatin (CDDP) was given to 19 patients with recurrent colorectal cancer resistant to 5-FU based chemotherapy. The 19 patients consisted of 18 men and 1 woman with a mean age of 61.3 years. Nine patients had liver metastasis, 4 had lung metastasis, 2 had local recurrence, 2 had both local recurrence and lung metastasis, respectively, 1 had local metastasis and lymph node metastasis, and 1 had bone metastasis. CPT-11 (80 mg/m2) and CDDP (30 mg/m2) were administered bi-weekly. The objective overall response rate was 15.8%. The time to progression was 146 days, and the median survival time was 477 days. Grade 3 leucopenia and nausea occurred in 1 patient (5.3%). CPT-11 and CDDP treatment should be considered as second-line chemotherapy for colorectal cancer resistant to 5-FU based chemotherapy.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0385-0684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1007-10
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16044963-Adult,
pubmed-meshheading:16044963-Aged,
pubmed-meshheading:16044963-Alopecia,
pubmed-meshheading:16044963-Anorexia,
pubmed-meshheading:16044963-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16044963-Camptothecin,
pubmed-meshheading:16044963-Cisplatin,
pubmed-meshheading:16044963-Colonic Neoplasms,
pubmed-meshheading:16044963-Drug Administration Schedule,
pubmed-meshheading:16044963-Drug Resistance, Neoplasm,
pubmed-meshheading:16044963-Female,
pubmed-meshheading:16044963-Fluorouracil,
pubmed-meshheading:16044963-Humans,
pubmed-meshheading:16044963-Liver Neoplasms,
pubmed-meshheading:16044963-Lung Neoplasms,
pubmed-meshheading:16044963-Lymphatic Metastasis,
pubmed-meshheading:16044963-Male,
pubmed-meshheading:16044963-Middle Aged,
pubmed-meshheading:16044963-Nausea,
pubmed-meshheading:16044963-Neoplasm Recurrence, Local,
pubmed-meshheading:16044963-Rectal Neoplasms
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
[Second-line chemotherapy with bi-weekly CPT-11 and cisplatin for recurrent colorectal cancer resistant to 5-FU based chemotherapy].
|
| pubmed:affiliation |
Hachioji Digestive Disease Hospital.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|