| pubmed-article:16041409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0023823 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0507850 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0008387 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0522534 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:16041409 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16041409 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16041409 | pubmed:dateCreated | 2005-8-2 | lld:pubmed |
| pubmed-article:16041409 | pubmed:abstractText | Plasma LDL levels and atherosclerosis both increase on a saturated fat-rich (SAT) diet. LDL cholesterol delivery to tissue may occur via uptake of the LDL particles or via selective uptake (SU), wherein cholesteryl ester (CE) enters cells without concomitant whole-particle uptake. It is not known how dietary fats might directly affect arterial LDL-CE uptake and whether SU is involved. Thus, mice that are relatively atherosclerosis resistant (C57BL/6) or susceptible to atherosclerosis (apoE) were fed a chow or SAT diet and injected with double radiolabeled or fluorescent-labeled human LDL to independently trace LDL-CE core and whole-particle uptake, respectively. Our results show that a SAT diet increased contributions of SU to total arterial LDL-CE delivery in C57BL/6 and apoE mice. The SAT diet increased plasma fatty acid and cholesterol levels; cholesterol, but not fatty acid, levels correlated with SU, as did the degree of atherosclerosis. Increased SU did not correlate with arterial scavenger receptor class B type I levels but paralleled increased lipoprotein lipase (LPL) levels and LPL distribution in the arterial wall. These studies suggest that arterial LDL-CE delivery via SU can be an important mechanism in vivo and that dietary influences on arterial LPL levels and atherogenesis modulate arterial LDL-CE delivery, cholesterol deposition, and SU. | lld:pubmed |
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| pubmed-article:16041409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16041409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16041409 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16041409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16041409 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16041409 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:WorgallTilla... | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:SeoToruT | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:DeckelbaumRic... | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:LiuYingY | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:QiKeminK | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:RamakrishnanR... | lld:pubmed |
| pubmed-article:16041409 | pubmed:author | pubmed-author:ChangChuchunC | lld:pubmed |
| pubmed-article:16041409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16041409 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:16041409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16041409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16041409 | pubmed:pagination | 2214-22 | lld:pubmed |
| pubmed-article:16041409 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:meshHeading | pubmed-meshheading:16041409... | lld:pubmed |
| pubmed-article:16041409 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16041409 | pubmed:articleTitle | Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall. | lld:pubmed |
| pubmed-article:16041409 | pubmed:affiliation | Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. ts227@columbia.edu | lld:pubmed |
| pubmed-article:16041409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16041409 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16041409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16041409 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
