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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-2
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pubmed:abstractText |
Plasma LDL levels and atherosclerosis both increase on a saturated fat-rich (SAT) diet. LDL cholesterol delivery to tissue may occur via uptake of the LDL particles or via selective uptake (SU), wherein cholesteryl ester (CE) enters cells without concomitant whole-particle uptake. It is not known how dietary fats might directly affect arterial LDL-CE uptake and whether SU is involved. Thus, mice that are relatively atherosclerosis resistant (C57BL/6) or susceptible to atherosclerosis (apoE) were fed a chow or SAT diet and injected with double radiolabeled or fluorescent-labeled human LDL to independently trace LDL-CE core and whole-particle uptake, respectively. Our results show that a SAT diet increased contributions of SU to total arterial LDL-CE delivery in C57BL/6 and apoE mice. The SAT diet increased plasma fatty acid and cholesterol levels; cholesterol, but not fatty acid, levels correlated with SU, as did the degree of atherosclerosis. Increased SU did not correlate with arterial scavenger receptor class B type I levels but paralleled increased lipoprotein lipase (LPL) levels and LPL distribution in the arterial wall. These studies suggest that arterial LDL-CE delivery via SU can be an important mechanism in vivo and that dietary influences on arterial LPL levels and atherogenesis modulate arterial LDL-CE delivery, cholesterol deposition, and SU.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-10377176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-10750690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-10772649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-10872459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-10896681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-11863451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-12069577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-12235173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-12569168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-12923293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-14563829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-15143347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-1649887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-2590067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-2767215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-3513311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-3598712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-4052149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-7541795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-7696328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-8663101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-901618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9144091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9168784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9261096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9261189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9391072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9555943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9575160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9643358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9684736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16041409-9748213
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2214-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16041409-Animals,
pubmed-meshheading:16041409-Apolipoproteins E,
pubmed-meshheading:16041409-Arteries,
pubmed-meshheading:16041409-Arteriosclerosis,
pubmed-meshheading:16041409-Cholesterol, LDL,
pubmed-meshheading:16041409-Cholesterol Esters,
pubmed-meshheading:16041409-Diet, Atherogenic,
pubmed-meshheading:16041409-Dietary Fats,
pubmed-meshheading:16041409-Fatty Acids,
pubmed-meshheading:16041409-Humans,
pubmed-meshheading:16041409-Lipoprotein Lipase,
pubmed-meshheading:16041409-Membrane Proteins,
pubmed-meshheading:16041409-Mice,
pubmed-meshheading:16041409-Mice, Knockout,
pubmed-meshheading:16041409-Receptors, Lipoprotein,
pubmed-meshheading:16041409-Scavenger Receptors, Class B
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pubmed:year |
2005
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pubmed:articleTitle |
Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall.
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pubmed:affiliation |
Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. ts227@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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