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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2005-10-10
pubmed:abstractText
Reactive oxygen species (ROS) have pathogenic effects on ischemic-reperfusion injury of heart. Hence, it is important to identify natural antioxidative agents to mitigate such effects. Recently, it has been reported that Clerodendron colebrookianum (CC) leaf extract has antioxidant and hypolipidemic effects in experimental animals. The aim of this study was to examine whether acute treatment with CC extract offers protection against ischemic-reperfusion injury (IRI) and IRI-induced changes in endogenous antioxidant enzyme activities of rat heart. Isolated rat hearts were perfused using the Langendorff's technique, and 20 min of global ischemia was followed by 40 min of reperfusion. Lipid peroxidation after the ischemic-reperfusion episode was significantly reduced in the CC extract-treated heart compared to the control group and suppressed the leakage of lactate dehydrogenase (LDH) during reperfusion. Moreover, CC extract diminished the depletion of myocardial antioxidant enzymes (SOD, Catalase, GSH and GPx) after ischemia-reperfusion. Furthermore, IRI-induced cellular damage was significantly less in CC extract treated myocytes. These results indicate that CC leaf extract protects against oxidative stress and cellular injury associated with ischemic-reperfusion injury of rat heart and suggests that the protective effects of CC extract depend on its antioxidant properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2999-3009
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16038942-Animals, pubmed-meshheading:16038942-Antioxidants, pubmed-meshheading:16038942-Catalase, pubmed-meshheading:16038942-Clerodendrum, pubmed-meshheading:16038942-Disease Models, Animal, pubmed-meshheading:16038942-Female, pubmed-meshheading:16038942-Glutathione Peroxidase, pubmed-meshheading:16038942-L-Lactate Dehydrogenase, pubmed-meshheading:16038942-Lipid Peroxidation, pubmed-meshheading:16038942-Male, pubmed-meshheading:16038942-Myocardial Reperfusion Injury, pubmed-meshheading:16038942-Myocardium, pubmed-meshheading:16038942-Oxidation-Reduction, pubmed-meshheading:16038942-Oxidative Stress, pubmed-meshheading:16038942-Plant Extracts, pubmed-meshheading:16038942-Rats, pubmed-meshheading:16038942-Rats, Wistar, pubmed-meshheading:16038942-Reactive Oxygen Species, pubmed-meshheading:16038942-Superoxide Dismutase
pubmed:year
2005
pubmed:articleTitle
Extract from Clerodendron colebrookianum Walp protects rat heart against oxidative stress induced by ischemic-reperfusion injury (IRI).
pubmed:affiliation
Institute of Advanced Study in Science and Technology, Guwahati-22, Assam, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't