16034114

Source:http://linkedlifedata.com/resource/pubmed/id/16034114

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0022688, umls-concept:C0035820, umls-concept:C0036957, umls-concept:C1155265
pubmed:issue	3
pubmed:dateCreated	2005-7-21
pubmed:abstractText	Shigella flexneri, an enteroinvasive Gram-negative bacterium, is responsible for the worldwide endemic form of bacillary dysentery. The host response to primary infection is characterized by the induction of an acute inflammation, which is accompanied by polymorphonuclear cell (PMN) infiltration, resulting in massive destruction of the colonic mucosa. However, PMN play a major role in the recovery from primary infection, by restricting the bacterial infection at the intestinal mucosa. In this study, we assessed the roles for T and NK cells in the control of primary S. flexneri infection, using an alymphoid mouse strain (Rag null gamma(c) null) devoid of B, T, and NK cells. Using the mouse pulmonary model of Shigella infection, we showed that alymphoid Rag null gamma(c) null mice were highly susceptible to S. flexneri infection in comparison with wild-type (wt) mice. Whereas PMN recruitment upon infection was similar, macrophage recruitment and production of proinflammatory cytokines were significantly decreased in Rag null gamma(c) null mice compared with wt mice. Upon selective engraftment of Rag null gamma(c) null mice with polyclonal alphabeta T cells, but not with alphabeta T cells from IFN-gamma null , S. flexneri infection could be subsequently controlled. Rag null mice devoid of B and T cells but harboring NK cells could control infection. Local IFN-gamma production by T and NK cells recruited to the lung was demonstrated in S. flexneri-infected wt mice. These data demonstrate that both alphabeta T cells and NK cells contribute to the early control of S. flexneri infection through amplification of an inflammatory response. This cellular lymphocyte redundancy assures IFN-gamma production, which is central to innate immunity against Shigella infection.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985117R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Il2rg protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin Receptor Common gamma..., http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein, http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7, http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0022-1767
pubmed:author	pubmed-author:CorcuffErwanE, pubmed-author:Di SantoJames PJP, pubmed-author:Le-BarillecKarineK, pubmed-author:MagalhaesJoao GamelasJG, pubmed-author:PhaliponArmelleA, pubmed-author:SansonettiPhilippe JPJ, pubmed-author:ThuizatAudreyA
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	175
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1735-40
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:16034114-Animals, pubmed-meshheading:16034114-DNA-Binding Proteins, pubmed-meshheading:16034114-Dysentery, Bacillary, pubmed-meshheading:16034114-Genetic Predisposition to Disease, pubmed-meshheading:16034114-Homeodomain Proteins, pubmed-meshheading:16034114-Immunity, Innate, pubmed-meshheading:16034114-Inflammation Mediators, pubmed-meshheading:16034114-Interferon-gamma, pubmed-meshheading:16034114-Interleukin Receptor Common gamma Subunit, pubmed-meshheading:16034114-Intestinal Mucosa, pubmed-meshheading:16034114-Killer Cells, Natural, pubmed-meshheading:16034114-Lung, pubmed-meshheading:16034114-Mice, pubmed-meshheading:16034114-Mice, Inbred C57BL, pubmed-meshheading:16034114-Mice, Knockout, pubmed-meshheading:16034114-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:16034114-Receptors, Interleukin-7, pubmed-meshheading:16034114-Shigella flexneri, pubmed-meshheading:16034114-T-Lymphocyte Subsets
pubmed:year	2005
pubmed:articleTitle	Roles for T and NK cells in the innate immune response to Shigella flexneri.
pubmed:affiliation	Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale, Unité 668, Paris cedex, France.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't