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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-7-20
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pubmed:abstractText |
Risk factors for adult glioma in the San Francisco Bay Area include well-known demographic features such as age and race/ethnicity, and our previous studies indicated that these characteristics are associated with the TP53 mutation status of patients' tumors. We enlarged our study to assess the relationships of risk factors with TP53 as well as epidermal growth factor receptor (EGFR) and murine double minute-2 (MDM2) gene amplification and expression and the germ line Leu84Phe polymorphism in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT). MGMT expression may depend on the TP53 status of cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/O(6)-Methylguanine-DNA...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1055-9965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1774-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16030116-Astrocytoma,
pubmed-meshheading:16030116-Ethnic Groups,
pubmed-meshheading:16030116-Female,
pubmed-meshheading:16030116-Gene Amplification,
pubmed-meshheading:16030116-Genes, p53,
pubmed-meshheading:16030116-Glioblastoma,
pubmed-meshheading:16030116-Humans,
pubmed-meshheading:16030116-Male,
pubmed-meshheading:16030116-Middle Aged,
pubmed-meshheading:16030116-Molecular Biology,
pubmed-meshheading:16030116-Nuclear Proteins,
pubmed-meshheading:16030116-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:16030116-Polymorphism, Genetic,
pubmed-meshheading:16030116-Prevalence,
pubmed-meshheading:16030116-Proto-Oncogene Proteins,
pubmed-meshheading:16030116-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:16030116-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16030116-San Francisco,
pubmed-meshheading:16030116-Tumor Markers, Biological,
pubmed-meshheading:16030116-Tumor Suppressor Protein p53
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pubmed:year |
2005
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pubmed:articleTitle |
Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase.
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pubmed:affiliation |
Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California San Francisco, Box 0441, San Francisco, CA 94143-0441, USA. Wiencke@itsa.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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