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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
30
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pubmed:dateCreated |
2005-7-27
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pubmed:abstractText |
Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The defect was not observed in mice with an endothelium-restricted deficiency of the protein but was still detectable in mice transplanted with bone marrow from JAM-A(-/-) donors. Microscopic examination of mesenteric and heart microvasculature of JAM-A(-/-) mice showed high numbers of PMN adherent on the endothelium or entrapped between endothelial cells and the basement membrane. In vitro, in the absence of JAM-A, PMN adhered more efficiently to endothelial cells and basement membrane proteins, and their polarized movement was strongly reduced. This paper describes a nonredundant role of JAM-A in controlling PMN diapedesis through the vessel wall.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-10072554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-10544206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-10559877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-10586087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-10945976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11035102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11053409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11390508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11448997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11739175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11744011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11812992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-11823489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-12208882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-12231354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-12239159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-12417630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-12610627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-14657270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-14657486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15071551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15343392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15366706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15378136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15611287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15662021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15677455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15681301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-15827135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-3976847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-7544874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-7592728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-7882499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-8113674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-8666673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-9660867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16027360-9674738
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:BossiMarioM,
pubmed-author:CeraMaria RosariaMR,
pubmed-author:ChimentiStefanoS,
pubmed-author:CoradaMonicaM,
pubmed-author:De AngelisNoeleenN,
pubmed-author:DejanaElisabettaE,
pubmed-author:FiordalisoFabioF,
pubmed-author:LatiniRobertoR,
pubmed-author:MotoikeToshiyukiT,
pubmed-author:ParazzoliDarioD,
pubmed-author:SalioMonicaM,
pubmed-author:StaszewskyLidia ILI,
pubmed-author:VecchiAnnunciataA,
pubmed-author:VillaAntonelloA,
pubmed-author:VinciMariaM
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10634-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16027360-Animals,
pubmed-meshheading:16027360-Bone Marrow Transplantation,
pubmed-meshheading:16027360-Cell Adhesion,
pubmed-meshheading:16027360-Cell Adhesion Molecules,
pubmed-meshheading:16027360-Cell Movement,
pubmed-meshheading:16027360-Endothelium, Vascular,
pubmed-meshheading:16027360-Immunohistochemistry,
pubmed-meshheading:16027360-Mice,
pubmed-meshheading:16027360-Mice, Knockout,
pubmed-meshheading:16027360-Microscopy, Electron,
pubmed-meshheading:16027360-Neutrophils,
pubmed-meshheading:16027360-Peritonitis,
pubmed-meshheading:16027360-Reperfusion Injury
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pubmed:year |
2005
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pubmed:articleTitle |
Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.
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pubmed:affiliation |
Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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