Linked Life Data

16025473

Source:http://linkedlifedata.com/resource/pubmed/id/16025473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-8-16
pubmed:abstractText
Biodegradable methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic block copolymeric nanospheres were prepared for application as a particulate drug carrier. Drug-loaded nanospheres (ML50) showed a narrow size distribution with the average diameter of <200 nm. When the feed weight ratio of indomethacin (IMC) to polymer was 1:1, the ML50 nanosphere having a relatively high drug-loading efficiency of about 33.0% could be obtained. To investigate pharmacokinetic characteristics of IMC in rats, the IMC concentration in plasma was analyzed using a high-performance liquid chromatography system after intravenous bolus injection of free IMC and IMC-loaded ML50 nanospheres. ML50 nanosphere system exhibited a significant potential for sustained release of drug and showed slow clearance of IMC, but there was no significant effect on metabolism of IMC in the rats. Median lethal dose (LD50) and major organs (e.g., heart, lung, liver, and kidney) toxicities were determined using ICR mice to estimate the acute toxicity of ML50 nanospheres. The LD50 of ML50 nanospheres determined by Litchfield-Wilcoxon method was about 1.54 g/kg. After the mice were intraperitoneally administered with a half dose of LD50 for 7 days, no significant histopathologic changes were observed in ML50-treated mice compared with normal mice in the light and electron microscopic observations of major organs. This indicates that ML50 nanospheres might be a useful candidate as a novel sustained drug carrier for hydrophobic drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
(c) 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-90
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Indomethacin-loaded methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic diblock copolymeric nanospheres: pharmacokinetic and toxicity studies in rodents.
pubmed:affiliation
School of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133-791, South Korea.
pubmed:publicationType
Journal Article