Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-7-14
|
| pubmed:abstractText |
In guinea pig isolated ileum longitudinal muscle myenteric plexus, cholecystokinin octapeptide (CCK-8S) produced a rapid (phasic) contraction followed by a slower tonic phase. The tetrapeptide derivative CCK-4 and pentagastrin elicited only the phasic response up to 10(-6) M, whereas the tonic phase was also apparent at higher concentrations. The rank order of potency for the effect of agonists on the tonic and phasic responses were CCK-8S much greater than gastrin greater than CCK-8US congruent to pentagastrin greater than CCK-4 and CCK-8S greater than gastrin congruent to pentagastrin greater than CCK-4 greater than CCK-8US, respectively. Phasic responses of CCK-8S and CCK-4 were sensitive to atropine, whereas the tonic response could be completely abolished with the neurokinin-1 antagonist GR82334. The CCK-A receptor antagonist L-364,718 up to 10(-7) M had little effect on the phasic contracture of CCK-4. The CCK-B/gastrin receptor antagonist L-365,260 had no effect on the CCK-8S phasic response up to 10(-7) M, but antagonized the phasic response induced by low concentrations of CCK-4 in a competitive manner with an estimated pKB of 8.51. This value is close to that of 8.53 found in a guinea pig cortical binding assay. Both the second phase of the CCK-4 phasic concentration response curve (CRC) and the tonic contraction were insensitive to L-365,260.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-3565
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
261
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1056-63
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1602372-Animals,
pubmed-meshheading:1602372-Benzodiazepinones,
pubmed-meshheading:1602372-Brain,
pubmed-meshheading:1602372-Cholecystokinin,
pubmed-meshheading:1602372-Culture Techniques,
pubmed-meshheading:1602372-Devazepide,
pubmed-meshheading:1602372-Guinea Pigs,
pubmed-meshheading:1602372-Male,
pubmed-meshheading:1602372-Muscle, Smooth,
pubmed-meshheading:1602372-Muscle Contraction,
pubmed-meshheading:1602372-Myenteric Plexus,
pubmed-meshheading:1602372-Pancreas,
pubmed-meshheading:1602372-Rats,
pubmed-meshheading:1602372-Rats, Inbred Strains,
pubmed-meshheading:1602372-Receptors, Cholecystokinin
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Evidence for two cholecystokinin receptors mediating the contraction of the guinea pig isolated ileum longitudinal muscle myenteric plexus.
|
| pubmed:affiliation |
Glaxo Research Laboratories, Verona, Italy.
|
| pubmed:publicationType |
Journal Article
|